Deltex Homolog 1 Antikörper (AA 261-410)

Produktnummer ABIN7151013

Der Kaninchen Polyklonal Anti-Deltex Homolog 1-Antikörper wurde für ELISA und IF validiert. Er ist geeignet, Deltex Homolog 1 in Proben von Human zu detektieren.

Kurzübersicht für Deltex Homolog 1 Antikörper (AA 261-410) (ABIN7151013)

Target: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Deltex Homolog 1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-Deltex Homolog 1 Antikörper

Bindungsspezifität: AA 261-410

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase DTX1 protein (261-410AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Deltex Homolog 1

Target: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Andere Bezeichnung: DTX1

Hintergrund:

Background: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Aliases: Deltex 1, E3 ubiquitin ligase antibody, Deltex antibody, Deltex homolog 1 (Drosophila) antibody, Deltex homolog 1 antibody, Deltex protein 1 antibody, Deltex-1 antibody, Deltex1 antibody, dtx1 antibody, DTX1_HUMAN antibody, E3 ubiquitin protein ligase DTX1 antibody, E3 ubiquitin-protein ligase DTX1 antibody, FXI-T1 antibody, Fxit 1 antibody, Fxit1 antibody, hDTX1 antibody, hDx 1 antibody, mDTX1 antibody, Protein deltex 1 antibody, Protein deltex-1 antibody

UniProt: Q86Y01

Pathways: Notch Signalweg