CBLC Antikörper (AA 245-474)

Produktnummer ABIN7150999

Dieses Anti-CBLC-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CBLC in ELISA und IHC. Geeignet für Human.

Kurzübersicht für CBLC Antikörper (AA 245-474) (ABIN7150999)

Target: CBLC (Cbl proto-oncogene C (CBLC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLC Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CBLC Antikörper

Bindungsspezifität: AA 245-474

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CBLC

Target: CBLC (Cbl proto-oncogene C (CBLC))

Andere Bezeichnung: CBLC

Hintergrund:

Background: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at \\\'Tyr-419\\\'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.

Aliases: CBLC antibody, CBL3 antibody, RNF57E3 ubiquitin-protein ligase CBL-C antibody, EC 2.3.2.27 antibody, RING finger protein 57 antibody, RING-type E3 ubiquitin transferase CBL-C antibody, SH3-binding protein CBL-3 antibody, SH3-binding protein CBL-C antibody, Signal transduction protein CBL-C antibody

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway