RNF4 Antikörper (AA 471-724)

Produktnummer ABIN7150991

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RNF4 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RNF4 Antikörper (AA 471-724) (ABIN7150991)

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RNF4 Antikörper

Bindungsspezifität: AA 471-724

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase BRE1B protein (471-724AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RNF4

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Andere Bezeichnung: RNF4

Hintergrund:

Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of \'Lys-120\' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 \'Lys-4\' and \'Lys-79\' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.

Aliases: 95 kDa retinoblastoma associated protein antibody, 95 kDa retinoblastoma protein binding protein antibody, 95 kDa retinoblastoma-associated protein antibody, BRE 1B antibody, BRE1 B antibody, BRE1 E3 ubiquitin ligase homolog B antibody, BRE1-B antibody, BRE1B antibody, BRE1B_HUMAN antibody, DKFZp686K191 antibody, E3 ubiquitin protein ligase BRE1B antibody, E3 ubiquitin-protein ligase BRE1B antibody, KIAA0661 antibody, MGC13051 antibody, Rb associated protein antibody, RBP 95 antibody, RBP95 antibody, RING finger protein 40 antibody, Ring finger protein 40 E3 ubiquitin protein ligase antibody, RNF 40 antibody, Rnf40 antibody, STARING antibody

UniProt: O75150

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway