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RFX6 Antikörper (AA 1-260) (HRP)

This anti-RFX6 antibody (ABIN7150388) is a Rabbit Polyclonal antibody detecting RFX6 in ELISA. Suitable for Human.
Produktnummer ABIN7150388

Kurzübersicht für RFX6 Antikörper (AA 1-260) (HRP) (ABIN7150388)

Target

Alle RFX6 Antikörper anzeigen
RFX6 (Regulatory Factor X 6 (RFX6))

Reaktivität

  • 19
  • 10
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 17
  • 2
Kaninchen

Klonalität

  • 19
Polyklonal

Konjugat

  • 9
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser RFX6 Antikörper ist konjugiert mit HRP

Applikation

  • 6
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
ELISA
  • Bindungsspezifität

    • 4
    • 4
    • 1
    • 1
    • 1
    AA 1-260

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human DNA-binding protein RFX6 protein (1-260AA)

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    RFX6 (Regulatory Factor X 6 (RFX6))

    Andere Bezeichnung

    RFX6

    Hintergrund

    Background: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).

    Aliases: RFX6 antibody, RFXDC1 antibody, DNA-binding protein RFX6 antibody, Regulatory factor X 6 antibody, Regulatory factor X domain-containing protein 1 antibody

    UniProt

    Q8HWS3

    Pathways

    Carbohydrate Homeostasis
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