RFX6 Antikörper (AA 1-260)

Produktnummer ABIN7150385

Dieses Rabbit Polyclonal-Antikörper erkennt spezifisch RFX6 in ELISA, IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RFX6 Antikörper (AA 1-260) (ABIN7150385)

Target: RFX6 (Regulatory Factor X 6 (RFX6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFX6 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RFX6 Antikörper

Bindungsspezifität: AA 1-260

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human DNA-binding protein RFX6 protein (1-260AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RFX6

Target: RFX6 (Regulatory Factor X 6 (RFX6))

Andere Bezeichnung: RFX6

Hintergrund:

Background: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).

Aliases: RFX6 antibody, RFXDC1 antibody, DNA-binding protein RFX6 antibody, Regulatory factor X 6 antibody, Regulatory factor X domain-containing protein 1 antibody

UniProt: Q8HWS3

Pathways: Carbohydrate Homeostasis