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NDEL1 Antikörper (pSer242)

Der Rabbit Polyclonal Anti-NDEL1-Antikörper wurde für WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) validiert. Er ist geeignet, NDEL1 in Proben von Human, Mouse zu detektieren.
Produktnummer ABIN710816

Kurzübersicht für NDEL1 Antikörper (pSer242) (ABIN710816)

Target

Alle NDEL1 Antikörper anzeigen
NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Reaktivität

  • 66
  • 54
  • 49
  • 2
  • 1
Human, Maus

Wirt

  • 88
  • 5
  • 1
Kaninchen

Klonalität

  • 79
  • 15
Polyklonal

Konjugat

  • 24
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser NDEL1 Antikörper ist unkonjugiert

Applikation

  • 51
  • 51
  • 49
  • 20
  • 13
  • 11
  • 7
  • 5
  • 5
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 22
    • 15
    • 15
    • 14
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer242

    Kreuzreaktivität

    Human, Maus

    Homologie

    Rat,Cow,Pig,Horse,Chicken,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human NDEL1 around the phosphorylation site of Ser242

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

    Andere Bezeichnung

    NDEL1

    Hintergrund

    Synonyms: EOPA, NDE2, NUDEL, MITAP1, NDE1L1, Nuclear distribution protein nudE-like 1, Protein Nudel, Mitosin-associated protein 1, NDEL1

    Background: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

    Gen-ID

    81565

    UniProt

    Q9GZM8

    Pathways

    Regulation of Cell Size
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