DMAP1 Antikörper (AA 250-300) (Biotin)

Produktnummer ABIN7150198

Dieses Anti-DMAP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DMAP1 in ELISA. Geeignet für Human.

Kurzübersicht für DMAP1 Antikörper (AA 250-300) (Biotin) (ABIN7150198)

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMAP1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-DMAP1 Antikörper (Biotin)

Bindungsspezifität: AA 250-300

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human DNA methyltransferase 1-associated protein 1 protein (250-300AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DMAP1

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Andere Bezeichnung: DMAP1

Hintergrund:

Background: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

Aliases: DMAP1 antibody, KIAA1425DNA methyltransferase 1-associated protein 1 antibody, DNMAP1 antibody, DNMT1-associated protein 1 antibody

UniProt: Q9NPF5