ZRANB3 Antikörper (AA 370-624) (Biotin)

Produktnummer ABIN7150121

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ZRANB3 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ZRANB3 Antikörper (AA 370-624) (Biotin) (ABIN7150121)

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZRANB3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-ZRANB3 Antikörper (Biotin)

Bindungsspezifität: AA 370-624

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human DNA annealing helicase and endonuclease ZRANB3 protein (370-624AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ZRANB3

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Andere Bezeichnung: ZRANB3

Hintergrund:

Background: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3\\\'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Aliases: 4933425L19Rik antibody, AH2 antibody, Annealing helicase 2 antibody, DNA annealing helicase and endonuclease ZRANB3 antibody, MGC105033 antibody, MGC75012 antibody, OTTHUMP00000197449 antibody, Zinc finger Ran-binding domain-containing protein 3 antibody, Zinc finger, RAN- binding domain containing 3 antibody, ZRAB3_HUMAN antibody, Zranb3 antibody

UniProt: Q5FWF4