DLG5 Antikörper (AA 1580-1704) (Biotin)

Produktnummer ABIN7150081

Dieses Anti-DLG5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DLG5 in ELISA. Geeignet für Human.

Kurzübersicht für DLG5 Antikörper (AA 1580-1704) (Biotin) (ABIN7150081)

Target: DLG5 (Discs, Large Homolog 5 (DLG5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLG5 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-DLG5 Antikörper (Biotin)

Bindungsspezifität: AA 1580-1704

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Disks large homolog 5 protein (1580-1704AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DLG5

Target: DLG5 (Discs, Large Homolog 5 (DLG5))

Andere Bezeichnung: DLG5

Hintergrund:

Background: Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons, regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Aliases: Discs large homolog 5 (Drosophila) antibody, Discs large homolog 5 antibody, Discs large protein LP DLG antibody, Discs large protein P dlg antibody, Discs large protein P-dlg antibody, Disks large homolog 5 antibody, DLG 5 antibody, DLG5 antibody, DLG5_HUMAN antibody, KIAA0583 antibody, Large type of P DLG antibody, LP DLG antibody, P DLG5 antibody, PDLG antibody, Placenta and prostate DLG antibody

UniProt: Q8TDM6