ADAM10 Antikörper (AA 214-504)

Produktnummer ABIN7150034

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ADAM10 in IHC, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ADAM10 Antikörper (AA 214-504) (ABIN7150034)

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-ADAM10 Antikörper

Bindungsspezifität: AA 214-504

Verwendungszweck: ADAM10 Antibody

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Human Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Andere Bezeichnung: ADAM10

Hintergrund:

Background: Cleaves the membrane-bound precursor of TNF-alpha at \\\'76-Ala-|-Val-77\\\' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Aliases: A disintegrin and metalloprotease domain 10 antibody, A disintegrin and metalloproteinase domain 10 antibody, AD 10 antibody, AD10 antibody, AD18 antibody, ADA10_HUMAN antibody, ADAM 10 antibody, ADAM metallopeptidase domain 10 antibody, ADAM10 antibody, CD 156c antibody, CD156c antibody, CD156c antigen antibody, CDw156 antibody, disintegrin and metalloproteinase domain containing protein 10 antibody, Disintegrin and metalloproteinase domain-containing protein 10 antibody, HsT 18717 antibody, HsT18717 antibody, Kuz antibody, Kuzbanian antibody, Kuzbanian protein homolog antibody, Kuzbanian, Drosophila, homolog of antibody, MADM antibody, Mammalian disintegrin metalloprotease antibody, Mammalian disintegrin-metalloprotease antibody, RAK antibody

UniProt: O14672

Pathways: Notch Signalweg, EGFR Signaling Pathway