CDT2/RAMP Antikörper (AA 393-550) (HRP)

Produktnummer ABIN7149694

Dieses Anti-CDT2/RAMP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CDT2/RAMP in ELISA. Geeignet für Human.

Kurzübersicht für CDT2/RAMP Antikörper (AA 393-550) (HRP) (ABIN7149694)

Target: CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDT2/RAMP Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-CDT2/RAMP Antikörper (HRP)

Bindungsspezifität: AA 393-550

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Denticleless protein homolog protein (393-550AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CDT2/RAMP

Target: CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Andere Bezeichnung: DTL

Hintergrund:

Background: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the \'K+4\' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the \'Lys-164\' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613).

Aliases: Lethal(2) denticleless protein homolog antibody, CDW1 antibody, DCAF2 antibody, DDB1 and CUL4 associated factor 2 antibody, Ddb1- and Cul4-associated factor 2 antibody, Denticleless homolog antibody, Denticleless homolog (Drosophila) antibody, Denticleless protein homolog antibody, Dtl antibody, DTL_HUMAN antibody, L2DTL antibody, Lethal(2) denticleless protein homolog antibody, RA regulated nuclear matrix associated protein antibody, RAMP antibody, Retinoic acid regulated nuclear matrix associated protein antibody, Retinoic acid-regulated nuclear matrix-associated protein antibody

UniProt: Q9NZJ0