DAPK3 Antikörper (AA 283-401) (FITC)

Produktnummer ABIN7149560

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DAPK3 in . Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DAPK3 Antikörper (AA 283-401) (FITC) (ABIN7149560)

Target: DAPK3 (Death-Associated Protein Kinase 3 (DAPK3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DAPK3 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-DAPK3 Antikörper (FITC)

Bindungsspezifität: AA 283-401

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Death-associated protein kinase 3 protein (283-401AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DAPK3

Target: DAPK3 (Death-Associated Protein Kinase 3 (DAPK3))

Andere Bezeichnung: DAPK3

Hintergrund:

Background: Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on \'Ser-77\' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.

Aliases: DAP kinase 3 antibody, DAP like kinase antibody, DAP-like kinase antibody, Dapk 3 antibody, DAPK3 antibody, DAPK3_HUMAN antibody, Death associated kinase 3 antibody, Death associated protein kinase 3 antibody, Death-associated protein kinase 3 antibody, Dlk antibody, EC 2.7.11.1 antibody, FLJ36473 antibody, MYPT1 kinase antibody, ZIP antibody, ZIP kinase antibody, ZIP kinase isoform antibody, ZIP-kinase antibody, ZIPK antibody, zipper-interacting protein kinase antibody

UniProt: O43293