CPEB3 Antikörper (AA 414-525) (Biotin)

Produktnummer ABIN7149345

Der Kaninchen Polyklonal Anti-CPEB3-Antikörper wurde für ELISA validiert. Er ist geeignet, CPEB3 in Proben von Human zu detektieren.

Kurzübersicht für CPEB3 Antikörper (AA 414-525) (Biotin) (ABIN7149345)

Target: CPEB3 (Cytoplasmic Polyadenylation Element Binding Protein 3 (CPEB3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPEB3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-CPEB3 Antikörper (Biotin)

Bindungsspezifität: AA 414-525

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Cytoplasmic polyadenylation element-binding protein 3 protein (414-525AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CPEB3

Target: CPEB3 (Cytoplasmic Polyadenylation Element Binding Protein 3 (CPEB3))

Andere Bezeichnung: CPEB3

Hintergrund:

Background: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3\'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3\'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3\'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195).

Aliases: CPE-binding protein 3 antibody, CPE-BP3 antibody, CPEB 3 antibody, CPEB3 antibody, CPEB3_HUMAN antibody, Cytoplasmic polyadenylation element binding protein 3 antibody, Cytoplasmic polyadenylation element-binding protein 3 antibody, hCPEB-3 antibody, KIAA0940 antibody

UniProt: Q8NE35