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Cullin 4B Antikörper (AA 1-200)

CUL4B Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7148757
  • Target Alle Cullin 4B (CUL4B) Antikörper anzeigen
    Cullin 4B (CUL4B)
    Bindungsspezifität
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-200
    Reaktivität
    • 60
    • 22
    • 21
    • 9
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 55
    • 5
    Kaninchen
    Klonalität
    • 57
    • 3
    Polyklonal
    Konjugat
    • 32
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Cullin 4B Antikörper ist unkonjugiert
    Applikation
    • 41
    • 18
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Cullin-4B protein (1-200AA)
    Isotyp
    IgG
    Top Product
    Discover our top product CUL4B Primärantikörper
  • Applikationshinweise
    Recommended dilution: IHC:1:20-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Cullin 4B (CUL4B)
    Andere Bezeichnung
    CUL4B (CUL4B Produkte)
    Synonyme
    MRXHF2 antikoerper, MRXS15 antikoerper, MRXSC antikoerper, SFM2 antikoerper, 2700050M05Rik antikoerper, AA409770 antikoerper, CUL-4B antikoerper, mKIAA0695 antikoerper, RGD1564494 antikoerper, im:7140950 antikoerper, im:7150765 antikoerper, MGC115611 antikoerper, Tb03.1J15.620 antikoerper, sfm2 antikoerper, mrxsc antikoerper, mrxhf2 antikoerper, cullin 4B antikoerper, cullin 4B S homeolog antikoerper, CUL4B antikoerper, Cul4b antikoerper, cul4b antikoerper, cul4b.S antikoerper, Tb927.3.1290 antikoerper
    Hintergrund

    Background: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

    Aliases: CUL 4B antibody, CUL-4B antibody, CUL4B antibody, CUL4B_HUMAN antibody, Cullin-4B antibody, DKFZp686F1470 antibody, KIAA0695 antibody, MRXHF2 antibody, MRXSC antibody, SFM2 antibody

    UniProt
    Q13620
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