CH25H Antikörper (AA 142-272) (HRP)

Produktnummer ABIN7147603

Dieses Anti-CH25H-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CH25H in ELISA. Geeignet für Human.

Kurzübersicht für CH25H Antikörper (AA 142-272) (HRP) (ABIN7147603)

Target: CH25H (Cholesterol 25-Hydroxylase (CH25H))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CH25H Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-CH25H Antikörper (HRP)

Bindungsspezifität: AA 142-272

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Cholesterol 25-hydroxylase protein (142-272AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CH25H

Target: CH25H (Cholesterol 25-Hydroxylase (CH25H))

Andere Bezeichnung: CH25H

Hintergrund:

Background: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

Aliases: CH25H antibody, Cholesterol 25-hydroxylase antibody, EC 1.14.99.38 antibody, Cholesterol 25-monooxygenase antibody, h25OH antibody

UniProt: O95992