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CH25H Antikörper (AA 142-272)

Dieses Anti-CH25H-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CH25H in ELISA und IHC. Geeignet für Human.
Produktnummer ABIN7147600

Kurzübersicht für CH25H Antikörper (AA 142-272) (ABIN7147600)

Target

Alle CH25H Antikörper anzeigen
CH25H (Cholesterol 25-Hydroxylase (CH25H))

Reaktivität

  • 17
  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 27
  • 4
Kaninchen

Klonalität

  • 28
  • 3
Polyklonal

Konjugat

  • 13
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CH25H Antikörper ist unkonjugiert

Applikation

  • 26
  • 8
  • 8
  • 4
  • 2
  • 2
  • 1
ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 142-272

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Cholesterol 25-hydroxylase protein (142-272AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: IHC:1:20-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    CH25H (Cholesterol 25-Hydroxylase (CH25H))

    Andere Bezeichnung

    CH25H

    Hintergrund

    Background: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

    Aliases: CH25H antibody, Cholesterol 25-hydroxylase antibody, EC 1.14.99.38 antibody, Cholesterol 25-monooxygenase antibody, h25OH antibody

    UniProt

    O95992
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