CSNK2A2 Antikörper (AA 8-350) (Biotin)

Produktnummer ABIN7146889

Dieses Anti-CSNK2A2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CSNK2A2 in ELISA. Geeignet für Human.

Kurzübersicht für CSNK2A2 Antikörper (AA 8-350) (Biotin) (ABIN7146889)

Target: CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSNK2A2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-CSNK2A2 Antikörper (Biotin)

Bindungsspezifität: AA 8-350

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Casein kinase II subunit alpha' protein (8-350AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CSNK2A2

Target: CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))

Andere Bezeichnung: CSNK2A2

Hintergrund:

Background: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Aliases: Casein kinase 2 alpha prime polypeptide antibody, Casein kinase II alpha' chain antibody, Casein kinase II subunit alpha' antibody, CK II alpha' antibody, CK II antibody, CK2A2 antibody, CKII antibody, CSK22_HUMAN antibody, CSNK2A1 antibody, CSNK2A2 antibody, FLJ43934 antibody

UniProt: P19784

Pathways: SARS-CoV-2 Protein Interaktom