SS18L1 Antikörper (AA 47-396)

Produktnummer ABIN7146400

Dieses Anti-SS18L1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SS18L1 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für SS18L1 Antikörper (AA 47-396) (ABIN7146400)

Target: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SS18L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SS18L1 Antikörper

Bindungsspezifität: AA 47-396

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Calcium-responsive transactivator protein (47-396AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SS18L1

Target: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Andere Bezeichnung: SS18L1

Hintergrund:

Background: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).

Aliases: Calcium-responsive transactivator antibody, CREST antibody, CREST_HUMAN antibody, KIAA0693 antibody, LP2261 antibody, MGC26711 antibody, MGC78386 antibody, sarcoma translocation gene on chromosome18like1 antibody, SS18 antibody, SS18-like protein 1 antibody, SS18L1 antibody, SS18L1 nBAF chromatin remodeling complex antibody, SSXT antibody, synovial sarcoma translocation antibody, synovial sarcoma translocation gene on chromosome 18-like 1 antibody, SYT homolog 1 antibody

UniProt: O75177