EFHA1 Antikörper (AA 26-247)

Produktnummer ABIN7146326

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EFHA1 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für EFHA1 Antikörper (AA 26-247) (ABIN7146326)

Target: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EFHA1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-EFHA1 Antikörper

Bindungsspezifität: AA 26-247

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EFHA1

Target: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Andere Bezeichnung: MICU2

Hintergrund:

Background: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).

Aliases: 1110008L20Rik antibody, EF hand domain containing family member A1 antibody, EF hand domain family A1 antibody, EF hand domain family member A1 antibody, EF-hand domain-containing family member A1 antibody, EFHA1 antibody, EFHA1 EF hand domain family member A1 antibody, EFHA1_HUMAN antibody, FLJ25016 antibody, FLJ34588 antibody, Smhs2 homolog antibody

UniProt: Q8IYU8