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MCU Antikörper (AA 155-233) (HRP)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MCU in ELISA. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7146317

Kurzübersicht für MCU Antikörper (AA 155-233) (HRP) (ABIN7146317)

Target

Alle MCU Antikörper anzeigen
MCU (Mitochondrial Calcium Uniporter (MCU))

Reaktivität

  • 19
  • 11
  • 2
  • 1
Human

Wirt

  • 19
Kaninchen

Klonalität

  • 19
Polyklonal

Konjugat

  • 9
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MCU Antikörper ist konjugiert mit HRP

Applikation

  • 9
  • 8
  • 7
  • 1
  • 1
ELISA
  • Bindungsspezifität

    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 155-233

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Calcium uniporter protein, mitochondrial protein (155-233AA)

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    MCU (Mitochondrial Calcium Uniporter (MCU))

    Andere Bezeichnung

    MCU

    Hintergrund

    Background: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2, at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity).

    Aliases: MCU antibody, C10orf42 antibody, CCDC109ACalcium uniporter protein antibody, mitochondrial antibody, HsMCU antibody, Coiled-coil domain-containing protein 109A antibody

    UniProt

    Q8NE86

    Pathways

    Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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