ZNF224 Antikörper (AA 206-463)

Produktnummer ABIN7145868

Der Kaninchen Polyklonal Anti-ZNF224-Antikörper wurde für ELISA und IF validiert. Er ist geeignet, ZNF224 in Proben von Human zu detektieren.

Kurzübersicht für ZNF224 Antikörper (AA 206-463) (ABIN7145868)

Target: ZNF224 (Zinc Finger Protein 224 (ZNF224))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNF224 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-ZNF224 Antikörper

Bindungsspezifität: AA 206-463

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ZNF224

Target: ZNF224 (Zinc Finger Protein 224 (ZNF224))

Andere Bezeichnung: ZNF27

Hintergrund:

Background: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Aliases: Zinc finger protein 207 antibody, ZN207_HUMAN antibody, ZNF 207 antibody, ZNF207 antibody

UniProt: O43670