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KCTD6 Antikörper (AA 1-237) (Biotin)

KCTD6 Reaktivität: Human ELISA Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN7145857
  • Target Alle KCTD6 Antikörper anzeigen
    KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-237
    Reaktivität
    • 26
    • 12
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 24
    • 2
    Kaninchen
    Klonalität
    • 26
    Polyklonal
    Konjugat
    • 13
    • 4
    • 3
    • 2
    • 2
    • 2
    Dieser KCTD6 Antikörper ist konjugiert mit Biotin
    Applikation
    • 22
    • 16
    • 3
    • 2
    • 1
    ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
    Isotyp
    IgG
    Top Product
    Discover our top product KCTD6 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))
    Andere Bezeichnung
    KCTD6 (KCTD6 Produkte)
    Synonyme
    KCTD6 antikoerper, 5430433B02Rik antikoerper, AU044285 antikoerper, kctd6 antikoerper, zgc:91884 antikoerper, KCASH3 antikoerper, potassium channel tetramerization domain containing 6 antikoerper, potassium channel tetramerisation domain containing 6 antikoerper, potassium channel tetramerization domain containing 6b antikoerper, KCTD6 antikoerper, kctd6 antikoerper, Kctd6 antikoerper, kctd6b antikoerper
    Hintergrund

    Background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).

    Aliases: BTB/POZ domain-containing protein KCTD6 antibody, KCASH3 antibody, kctd6 antibody, KCTD6_HUMAN antibody, MGC27385 antibody, potassium channel tetramerization domain containing 6 antibody

    UniProt
    Q8NC69
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