AIRE Antikörper (AA 39-108) (Biotin)

Produktnummer ABIN7145088

Der Kaninchen Polyklonal Anti-AIRE-Antikörper wurde für ELISA validiert. Er ist geeignet, AIRE in Proben von Human zu detektieren.

Kurzübersicht für AIRE Antikörper (AA 39-108) (Biotin) (ABIN7145088)

Target: AIRE (Autoimmune Regulator (AIRE))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIRE Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-AIRE Antikörper (Biotin)

Bindungsspezifität: AA 39-108

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Autoimmune regulator protein (39-108AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu AIRE

Target: AIRE (Autoimmune Regulator (AIRE))

Andere Bezeichnung: AIRE

Hintergrund:

Background: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment, the preferred motif is a tandem repeat of 5\'-. ATTGGTTA-3\' combined with a 5\'-TTATTA-3\' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at \'Lys-4\', not phosphorylated at \'Thr-3\' and not methylated at \'Arg-2\'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

Aliases: AIRE antibody, AIRE_HUMAN antibody, AIRE1 antibody, APECED antibody, APECED protein antibody, APS1 antibody, APSI antibody, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody, Autoimmune regulator antibody, Autoimmune regulator protein antibody, PGA1 antibody

UniProt: O43918

Pathways: Chromatin Binding