Ataxin 3 Antikörper (AA 1-288)

Produktnummer ABIN7144793

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Ataxin 3 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Ataxin 3 Antikörper (AA 1-288) (ABIN7144793)

Target: Ataxin 3 (ATXN3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ataxin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Ataxin 3 Antikörper

Bindungsspezifität: AA 1-288

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ataxin-3 protein (1-288AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Ataxin 3

Target: Ataxin 3 (ATXN3)

Andere Bezeichnung: ATXN3

Hintergrund:

Background: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription.

Aliases: AT3 antibody, Ataxin 3 antibody, ataxin 3 variant h antibody, ataxin 3 variant m antibody, ataxin 3 variant ref antibody, Ataxin-3 antibody, ATX3 antibody, ATX3_HUMAN antibody, ATXN3 antibody, EC 3.4.22. antibody, JOS antibody, Josephin antibody, Machado Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) antibody, Machado Joseph disease antibody, Machado Joseph disease protein 1 antibody, Machado-Joseph disease protein 1 antibody, Machado-Joseph disease protein 1 homolog antibody, MJD antibody, MJD gene antibody, MJD1 antibody, Olivopontocerebellar ataxia 3 antibody, OTTHUMP00000221583 antibody, OTTHUMP00000221585 antibody, OTTHUMP00000221586 antibody, OTTHUMP00000221587 antibody, OTTHUMP00000231995 antibody, OTTHUMP00000231997 antibody, Rsca3 antibody, SCA3 antibody, SCA3 gene antibody, Spinocerebellar ataxia type 3 protein antibody

UniProt: P54252