AAK1 Antikörper (AA 274-465) (Biotin)

Produktnummer ABIN7144391

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch AAK1 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für AAK1 Antikörper (AA 274-465) (Biotin) (ABIN7144391)

Target: AAK1 (AP2 associated kinase 1 (AAK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AAK1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-AAK1 Antikörper (Biotin)

Bindungsspezifität: AA 274-465

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu AAK1

Target: AAK1 (AP2 associated kinase 1 (AAK1))

Andere Bezeichnung: AAK1

Hintergrund:

Background: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

Aliases: AAK 1 antibody, Aak1 antibody, AAK1_HUMAN antibody, Adaptor associated kinase 1 antibody, Adaptor-associated kinase 1 antibody, AP2 associated kinase 1 antibody, AP2 associated protein kinase 1 antibody, AP2-associated protein kinase 1 antibody, DKFZp686F03202 antibody, DKFZp686K16132 antibody, FLJ23712 antibody, FLJ25931 antibody, FLJ31060 antibody, FLJ42882 antibody, FLJ45252 antibody, KIAA1048 antibody, MGC138170 antibody, MGC164568 antibody, MGC164570 antibody

UniProt: Q2M2I8