A2ML1 Antikörper (AA 625-751)

Produktnummer ABIN7143798

Der Kaninchen Polyklonal Anti-A2ML1-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, A2ML1 in Proben von Human zu detektieren.

Kurzübersicht für A2ML1 Antikörper (AA 625-751) (ABIN7143798)

Target: A2ML1 (alpha-2-Macroglobulin-Like 1 (A2ML1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser A2ML1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-A2ML1 Antikörper

Bindungsspezifität: AA 625-751

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Alpha-2-macroglobulin-like protein 1 protein (625-751AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu A2ML1

Target: A2ML1 (alpha-2-Macroglobulin-Like 1 (A2ML1))

Andere Bezeichnung: A2ML1

Hintergrund:

Background: Is able to inhibit all four classes of proteinases by a unique \\\'trapping\\\' mechanism. This protein has a peptide stretch, called the \\\'bait region\\\' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

Aliases: A2ML1 antibody, CPAMD9Alpha-2-macroglobulin-like protein 1 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 antibody

UniProt: A8K2U0