ALKBH8 Antikörper (AA 1-230)

Produktnummer ABIN7143718

Dieses Anti-ALKBH8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ALKBH8 in ELISA und IHC. Geeignet für Human.

Kurzübersicht für ALKBH8 Antikörper (AA 1-230) (ABIN7143718)

Target: ALKBH8 (AlkB, Alkylation Repair Homolog 8 (ALKBH8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALKBH8 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ALKBH8 Antikörper

Bindungsspezifität: AA 1-230

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ALKBH8

Target: ALKBH8 (AlkB, Alkylation Repair Homolog 8 (ALKBH8))

Andere Bezeichnung: ALKBH8

Hintergrund:

Background: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine, has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).

Aliases: 4930562C03Rik antibody, 8030431D03Rik antibody, 9430088N01Rik antibody, ABH8 antibody, alkB alkylation repair homolog 8 (E. coli) antibody, alkB alkylation repair homolog 8 antibody, AlkB homologue 8 antibody, ALKB8_HUMAN antibody, ALKBH8 antibody, Alkylated DNA repair protein alkB homolog 8 antibody, FLJ38204 antibody, MGC10235 antibody, OTTHUMP00000211286 antibody, OTTHUMP00000211287 antibody, Probable alpha-ketoglutarate-dependent dioxygenase ABH8 antibody, RGD1304687 antibody, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 antibody, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 antibody

UniProt: Q96BT7