ARF1 Antikörper (AA 2-181) (HRP)

Produktnummer ABIN7143445

Dieses Anti-ARF1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ARF1 in ELISA. Geeignet für Human.

Kurzübersicht für ARF1 Antikörper (AA 2-181) (HRP) (ABIN7143445)

Target: ARF1 (ADP-Ribosylation Factor 1 (ARF1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARF1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-ARF1 Antikörper (HRP)

Bindungsspezifität: AA 2-181

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human ADP-ribosylation factor 1 protein (2-181AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ARF1

Target: ARF1 (ADP-Ribosylation Factor 1 (ARF1))

Andere Bezeichnung: ARF1

Hintergrund:

Background: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Aliases: ADP Ribosylation Factor 1 antibody, ADP-ribosylation factor 1 antibody, ARF 1 antibody, ARF1 antibody, ARF1_HUMAN antibody

UniProt: P84077

Pathways: Transition Metal Ion Homeostasis, Inositol Metabolic Process