Adhesion G Protein-Coupled Receptor G1 (ADGRG1) (AA 26-216) Antikörper (Biotin)

Produktnummer ABIN7143400

Dieses Anti--Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von in ELISA. Geeignet für Human.

Kurzübersicht für Adhesion G Protein-Coupled Receptor G1 (ADGRG1) (AA 26-216) Antikörper (Biotin) (ABIN7143400)

Target: Adhesion G Protein-Coupled Receptor G1 (ADGRG1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Biotin

Applikation: ELISA

Produktdetails

Bindungsspezifität: AA 26-216

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Adhesion G-protein coupled receptor G1 protein (26-216AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: Adhesion G Protein-Coupled Receptor G1 (ADGRG1)

Andere Bezeichnung: ADGRG1

Hintergrund:

Background: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).

Aliases: 7 transmembrane protein with no EGF like N terminal domains 1 antibody, BFPP antibody, DKFZp781L1398 antibody, EGF TM7 like antibody, G protein coupled receptor 56 antibody, G-protein coupled receptor 56 antibody, GPR 56 antibody, Gpr56 antibody, GPR56_HUMAN antibody, Polymicrogyria bilateral frontoparietal antibody, Protein TM7XN1 antibody, TM7LN4 antibody, TM7XN1 antibody, TM7XN1 protein antibody

UniProt: Q9Y653