FAM107A Antikörper (AA 1-144)

Produktnummer ABIN7143032

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FAM107A in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FAM107A Antikörper (AA 1-144) (ABIN7143032)

Target: FAM107A (Family with Sequence Similarity 107, Member A (FAM107A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM107A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FAM107A Antikörper

Bindungsspezifität: AA 1-144

Verwendungszweck: FAM107A Antibody

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Human Actin-associated protein FAM107A protein (1-144AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FAM107A

Target: FAM107A (Family with Sequence Similarity 107, Member A (FAM107A))

Andere Bezeichnung: FAM107A

Hintergrund:

Background: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization, negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580).

Aliases: Down regulated in renal cell carcinoma 1 antibody, Down-regulated in renal cell carcinoma 1 antibody, Downregulated in renal cell carcinoma antibody, DRR1 antibody, F107A_HUMAN antibody, FAM107A antibody, Family with sequence similarity 107, member A antibody, FLJ30158 antibody, FLJ45473 antibody, Protein FAM107A antibody, Protein TU3A antibody, TU3A antibody

UniProt: O95990