DCLRE1B Antikörper (AA 345-493)

Produktnummer ABIN7142656

Dieses Anti-DCLRE1B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DCLRE1B in ELISA und IF. Geeignet für Human.

Kurzübersicht für DCLRE1B Antikörper (AA 345-493) (ABIN7142656)

Target: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLRE1B Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-DCLRE1B Antikörper

Bindungsspezifität: AA 345-493

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human 5' exonuclease Apollo protein (345-493AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DCLRE1B

Target: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Andere Bezeichnung: DCLRE1B

Hintergrund:

Background: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

Aliases: DCLRE1B antibody, SNM1B5' exonuclease Apollo antibody, EC 3.1.-.- antibody, DNA cross-link repair 1B protein antibody, SNM1 homolog B antibody, SNMIB antibody, hSNM1B antibody

UniProt: Q9H816