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LexA (AA 1-202) Antikörper (HRP)

Reaktivität: E. coli ELISA Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN7141558
  • Target
    LexA
    Bindungsspezifität
    • 4
    • 1
    AA 1-202
    Reaktivität
    • 4
    • 1
    • 1
    E. coli
    Wirt
    • 6
    Kaninchen
    Klonalität
    • 6
    Polyklonal
    Konjugat
    • 3
    • 2
    • 1
    HRP
    Applikation
    • 3
    • 3
    ELISA
    Kreuzreaktivität
    E. coli
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Escherichia coli LexA repressor protein (1-202AA)
    Isotyp
    IgG
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    LexA
    Hintergrund

    Background: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5\'-CTGTATATATATACAG-3\'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).

    Aliases: lexA antibody, exrA antibody, spr antibody, tsl antibody, umuA antibody, b4043 antibody, JW4003LexA repressor antibody, EC 3.4.21.88 antibody

    UniProt
    P0A7C2
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