Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) Antikörper

Produktnummer ABIN7141316

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch in ELISA und WB. Er zeigt eine Reaktivität gegenüber Epstein-Barr Virus (EBV).

Kurzübersicht für Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) Antikörper (ABIN7141316)

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Reaktivität: Epstein-Barr Virus (EBV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 1-147

Verwendungszweck: LMP2 Antibody

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Andere Bezeichnung: Epstein-Barr virus LMP2

Hintergrund:

Background: Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.

Aliases: LMP2 antibody, Latent membrane protein 2 antibody, Terminal protein antibody

UniProt: P13285