RABAC1 Antikörper (AA 16-299) (FITC)

Produktnummer ABIN7140910

Dieses Anti-RABAC1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RABAC1 in . Geeignet für Candida albicans.

Kurzübersicht für RABAC1 Antikörper (AA 16-299) (FITC) (ABIN7140910)

Target: RABAC1 (Rab Acceptor 1 (Prenylated) (RABAC1))

Reaktivität: Candida albicans

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RABAC1 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-RABAC1 Antikörper (FITC)

Bindungsspezifität: AA 16-299

Kreuzreaktivität: Candida albicans

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RABAC1

Target: RABAC1 (Rab Acceptor 1 (Prenylated) (RABAC1))

Andere Bezeichnung: PRA1

Hintergrund:

Background: Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.

Aliases: PRA1 antibody, FBP1 antibody, CAALFM_C406980WA antibody, CaO19.10623 antibody, CaO19.3111 antibody, pH -regulated antigen PRA1 antibody, 58 kDa fibrinogen-binding mannoprotein antibody

UniProt: P87020

Pathways: Chromatin Binding