KRT17 Antikörper (AA 1-441) (Biotin)

Produktnummer ABIN7140839

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KRT17 in ELISA. Er zeigt eine Reaktivität gegenüber Rind (Kuh).

Kurzübersicht für KRT17 Antikörper (AA 1-441) (Biotin) (ABIN7140839)

Target: KRT17 (Keratin 17 (KRT17))

Reaktivität: Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KRT17 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-KRT17 Antikörper (Biotin)

Bindungsspezifität: AA 1-441

Kreuzreaktivität: Rind (Kuh)

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KRT17

Target: KRT17 (Keratin 17 (KRT17))

Andere Bezeichnung: KRT17

Hintergrund:

Background: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial \"stem cells\". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Aliases: KRT17 antibody, Keratin antibody, type I cytoskeletal 17 antibody, Cytokeratin-17 antibody, CK-17 antibody, Keratin-17 antibody, K17 antibody

UniProt: A1L595