CSK Antikörper

Produktnummer ABIN7140312

Der Maus Monoklonal Anti-CSK-Antikörper wurde für WB, ELISA und ICC validiert. Er ist geeignet, CSK in Proben von Human zu detektieren.

Kurzübersicht für CSK Antikörper (ABIN7140312)

Target: CSK (C-Src tyrosine Kinase (CSK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CSK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-CSK Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purified

Immunogen: Purified recombinant human CSK protein fragments expressed in E.coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine( pH 7.4,150 mM NaCl)with 0.2 % sodium azide,0.1 mg/mLBSA and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CSK

Target: CSK (C-Src tyrosine Kinase (CSK))

Andere Bezeichnung: CSK

Hintergrund:

Background: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Aliases: C SRC, C SRC kinase, C src Tyrosine Kinase, C-SRC kinase, c-src tyrosine kinase, Csk A, CSK, CSK_HUMAN, CYTOPLASMIC TYROSINE KINASE, EC2.7.10.2, MGC112926, MGC117393, MGC154049, P60 Src, Protein tyrosine kinase CYL, Protein-tyrosine kinase CYL,

UniProt: P41240

Pathways: T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events