Integrin beta 3 Antikörper (pTyr773)

Produktnummer ABIN7139067

Der Kaninchen Polyklonal Anti-Integrin beta 3-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, Integrin beta 3 in Proben von Human zu detektieren.

Kurzübersicht für Integrin beta 3 Antikörper (pTyr773) (ABIN7139067)

Target: Integrin beta 3 (ITGB3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Integrin beta 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Integrin beta 3 Antikörper

Bindungsspezifität: pTyr773

Kreuzreaktivität: Human, Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 773 (P-L-Y(p)-K-E) derived from Human Integrin b3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Andere Bezeichnung: ITGB3

Hintergrund:

Background: Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Chandhoke SK, et al. (2004) J Cell Sci.117 (Pt 8): 1431-1441.
Datta A, et al. (2002) J Biol Chem.277 (6): 3943-3949.
Law DA, et al. (1996) J Biol Chem.271 (18): 10811-10815.

Aliases: BDPLT16 antibody, BDPLT2 antibody, CD 61 antibody, CD61 antibody, CD61 antigen antibody, GP3A antibody, GPIIIa antibody, GT antibody, HPA 1 antibody, HPA 4 antibody, Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody, Integrin beta chain beta 3 antibody, Integrin beta-3 antibody, ITB3_HUMAN antibody, ITG B3 antibody, ITGB 3 antibody, ITGB3 antibody, NAIT antibody, platelet fibrinogen receptor antibody, Platelet fibrinogen receptor beta subunit antibody, Platelet fibrinogen receptor, beta subunit antibody, Platelet glycoprotein IIIa antibody, Platelet glycoprotein IIIa precursor antibody, Platelet membrane glycoprotein IIIa antibody, PTP antibody

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex