APP Antikörper (pThr668)

Produktnummer ABIN7138873

Dieses Anti-APP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von APP in WB und ELISA. Geeignet für Human.

Kurzübersicht für APP Antikörper (pThr668) (ABIN7138873)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-APP Antikörper

Bindungsspezifität: pThr668

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 668 (A-V-T(p)-P-E) derived from Human APP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Andere Bezeichnung: APP

Hintergrund:

Background:

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Hung, A.Y. and Selkoe, D.J. (1994) EMBO J. 13, 534-542.
Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122
Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427.
Iijima, K.I. et al. (2000) J. Neurochem. 75, 1085-1091

Aliases: A4 antibody, A4_HUMAN antibody, AAA antibody, ABETA antibody, ABPP antibody, AICD-50 antibody, AICD-57 antibody, AICD-59 antibody, AID(50) antibody, AID(57) antibody, AID(59) antibody, Alzheimer disease amyloid protein antibody, Amyloid intracellular domain 50 antibody, Amyloid intracellular domain 57 antibody, Amyloid intracellular domain 59 antibody, APP antibody, APPI antibody, Beta amyloid protein 42 antibody, Beta APP42 antibody, Beta-APP40 antibody, Beta-APP42 antibody, C31 antibody, Cerebral vascular amyloid peptide antibody, CVAP antibody, Gamma-CTF(50) antibody, Gamma-CTF(57) antibody, Gamma-CTF(59) antibody, PN-II antibody, PreA4 antibody, Protease nexin-II antibody, S-APP-alpha antibody, S-APP-beta antibody

UniProt: P05067

Pathways: Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour