KRT8 Antikörper (pSer74)

Produktnummer ABIN7138693

Der Kaninchen Polyklonal anti-KRT8 Antikörper (ABIN7138693) detektiert spezifisch KRT8 in WB, IF und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für KRT8 Antikörper (pSer74) (ABIN7138693)

Target: KRT8 (Keratin 8 (KRT8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KRT8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA

Produktdetails anti-KRT8 Antikörper

Bindungsspezifität: pSer74

Verwendungszweck: Phospho-KRT8 (Ser74) Antibody

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 74 (L-L-S(p)-P-L) derived from Human Keratin 8 (CK8).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KRT8

Target: KRT8 (Keratin 8 (KRT8))

Andere Bezeichnung: KRT8

Hintergrund:

Background:

Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.

Nakamichi I, et al. (2002) Mol Biol Cell, 13(10): 3441-3451.
Prochasson P, et al. (2002) Nucleic Acids Res, 30(15): 3312-3322.
Pankov R, et al. (1994) Proc Natl Acad Sci U S A, 91(3): 873-877.
Thorey IS, et al. (1993) Mol Cell Biol, 13(11): 6742-6751

Aliases: CARD2 antibody, CK 8 antibody, CK-8 antibody, CK8 antibody, CYK8 antibody, CYKER antibody, Cytokeratin endo A antibody, Cytokeratin-8 antibody, DreK8 antibody, EndoA antibody, K2C8 antibody, K2C8_HUMAN antibody, K8 antibody, Keratin 8 antibody, Keratin type II cytoskeletal 8 antibody, Keratin, type II cytoskeletal 8 antibody, Keratin-8 antibody, KO antibody, Krt 2.8 antibody, KRT8 antibody, MGC118110 antibody, MGC174782 antibody, MGC53564 antibody, MGC85764 antibody, sb:cb186 antibody, Type-II keratin Kb8 antibody

UniProt: P05787