alpha Adducin Antikörper (pSer726)

Produktnummer ABIN7138686

Der Kaninchen Polyklonal Anti-alpha Adducin-Antikörper wurde für WB, IHC, ELISA und IF validiert. Er ist geeignet, alpha Adducin in Proben von Human zu detektieren.

Kurzübersicht für alpha Adducin Antikörper (pSer726) (ABIN7138686)

Target: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser alpha Adducin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-alpha Adducin Antikörper

Bindungsspezifität: pSer726

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 726 (T-P-S(p)-F-L) derived from Human ADD1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu alpha Adducin

Target: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Andere Bezeichnung: ADD1

Hintergrund:

Background: Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms, however, not all variants have been fully described.

Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30, 102(35): 12407-12
Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01, 332(2): 347-51
Barkalow KL, et al. J Cell Biol 2003 May 12, 161(3): 557-70

Aliases: ADD A antibody, ADD1 antibody, ADDA antibody, ADDA_HUMAN antibody, Adducin 1 (alpha) antibody, Alpha adducin antibody, Alpha-adducin antibody, Erythrocyte adducin alpha subunit antibody, Erythrocyte adducin subunit alpha antibody, MGC3339 antibody, MGC44427 antibody, OTTHUMP00000151163 antibody, OTTHUMP00000151164 antibody, OTTHUMP00000151165 antibody, OTTHUMP00000218664 antibody, OTTHUMP00000218665 antibody

UniProt: P35611

Pathways: Negative Regulation of Hormone Secretion, Regulation of Actin Filament Polymerization, Regulation of Lipid Metabolism by PPARalpha, ER-Nucleus Signaling