Merlin Antikörper (pSer518)

Produktnummer ABIN7138643

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Merlin in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Merlin Antikörper (pSer518) (ABIN7138643)

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Merlin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-Merlin Antikörper

Bindungsspezifität: pSer518

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 518 (R-L-S(p)-M-E) derived from Human Merlin.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Andere Bezeichnung: NF2

Hintergrund:

Background:

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.

Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol , 25: 2384 - 2394.
Hi-Su Yang, et al. (2006) Cancer Res , 66: 2708 - 2715.
R Bohni, et al. (1994) J. Biol. Chem , 269: 14541 - 14545.
Adam J. Ratner, et al. (2001) J. Biol. Chem , 276: 19267 - 19275.

Aliases: ACN antibody, BANF antibody, Bilateral acoustic neuroma antibody, MERL_HUMAN antibody, Merlin antibody, Moesin ezrin radixin like protein antibody, Moesin ezrin radizin like antibody, Moesin-ezrin-radixin-like protein antibody, Neurofibromatosis 2 antibody, Neurofibromatosis type 2 antibody, Neurofibromatosis2 antibody, Neurofibromin 2 antibody, Neurofibromin-2 antibody, Neurofibromin2 antibody, NF 2 antibody, Nf2 antibody, SCH antibody, Schwannomerlin antibody, Schwannomin antibody

UniProt: P35240

Pathways: Cell-Cell Junction Organization