beta Arrestin 1 Antikörper (pSer412)

Produktnummer ABIN7138607

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch beta Arrestin 1 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für beta Arrestin 1 Antikörper (pSer412) (ABIN7138607)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Arrestin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-beta Arrestin 1 Antikörper

Bindungsspezifität: pSer412

Kreuzreaktivität: Human

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 412 (T-G-S(p)-P-Q) derived from Human Arrestin 1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Andere Bezeichnung: ARRB1

Hintergrund:

Background:

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein, the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Greg Buchanan. AACR Meeting Abstracts, Apr 2006, 2006: 430.
D. Alex Groarke. Mol. Pharmacol., Feb 2001, 59: 375.
Karen McConalogue. Mol. Biol. Cell, Aug 1998, 9: 2305.
Maria Stella Lombardi. Stroke, Apr 2004, 35: 981 - 986.

Aliases: ARB1 antibody, ARR1 antibody, ARRB1 antibody, ARRB1_HUMAN antibody, Arrestin 2 antibody, Arrestin beta 1 antibody, Arrestin beta-1 antibody, Beta-arrestin-1 antibody

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction