IRS1 Antikörper (pSer312)

Produktnummer ABIN7138549

Dieses Anti-IRS1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IRS1 in WB und ELISA. Geeignet für Human.

Kurzübersicht für IRS1 Antikörper (pSer312) (ABIN7138549)

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-IRS1 Antikörper

Bindungsspezifität: pSer312

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Peptide sequence around phosphorylation site of serine 312 (A-T-S(p)-P-A) derived from Human IRS-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu IRS1

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Andere Bezeichnung: IRS1

Hintergrund:

Background: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

Tzatsos A, et al. (2006) Mol Cell Biol, 26(1): 63-76
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645
Szanto I, et al. (2000) Proc Natl Acad Sci U S A, 97(5): 2355-2360
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645

Aliases: HIRS 1 antibody, HIRS1 antibody, Insulin receptor substrate 1 antibody, IRS 1 antibody, IRS-1 antibody, IRS1 antibody, IRS1_HUMAN antibody, OTTHUMP00000164234 antibody

UniProt: P35568

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process