SNAIL Antikörper (pSer246)

Produktnummer ABIN7138508

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch SNAIL in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SNAIL Antikörper (pSer246) (ABIN7138508)

Target: SNAIL (SNAI1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-SNAIL Antikörper

Bindungsspezifität: pSer246

Verwendungszweck: Phospho-SNAI1 (Ser246) Antibody

Kreuzreaktivität: Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SNAIL

Target: SNAIL (SNAI1)

Andere Bezeichnung: SNAI1

Hintergrund:

Background:

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Okubo T., Cancer Res. 61:1338-1346(2001).
Twigg S.R., Hum. Genet. 105:320-326(1999).
Paznekas W.A., Genomics 62:42-49(1999).

Aliases: dJ710H13.1 antibody, Protein sna antibody, Protein snail homolog 1 antibody, Protein snail homolog antibody, SLUGH2 antibody, SNA antibody, Sna protein antibody, SNAH antibody, SNAI antibody, snai1 antibody, SNAI1_HUMAN antibody, Snail 1 homolog antibody, Snail 1 zinc finger protein antibody, SNAIL antibody, Snail family transcriptional repressor 1 antibody, Snail homolog 1 (Drosophila) antibody, SNAIL, Drosophila, homolog of, 1 antibody, SNAIL1 antibody, Zinc finger protein SNAI1 antibody

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling