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SNAIL Antikörper (pSer246)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SNAIL in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7138508

Kurzübersicht für SNAIL Antikörper (pSer246) (ABIN7138508)

Target

Alle SNAIL (SNAI1) Antikörper anzeigen
SNAIL (SNAI1)

Reaktivität

  • 87
  • 38
  • 18
  • 6
  • 3
  • 3
  • 3
  • 1
  • 1
Human

Wirt

  • 72
  • 13
  • 3
  • 2
Kaninchen

Klonalität

  • 77
  • 13
Polyklonal

Konjugat

  • 66
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser SNAIL Antikörper ist unkonjugiert

Applikation

  • 68
  • 42
  • 37
  • 20
  • 11
  • 7
  • 7
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF)
  • Bindungsspezifität

    • 13
    • 12
    • 11
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer246

    Kreuzreaktivität

    Human, Maus

    Aufreinigung

    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

    Immunogen

    Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1.

    Isotyp

    IgG
  • Applikationshinweise

    WB:1:500-1:1000, IF:1:100-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    SNAIL (SNAI1)

    Andere Bezeichnung

    SNAI1

    Hintergrund

    Background:

    Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

    Okubo T., Cancer Res. 61:1338-1346(2001).
    Twigg S.R., Hum. Genet. 105:320-326(1999).
    Paznekas W.A., Genomics 62:42-49(1999).

    Aliases: dJ710H13.1 antibody, Protein sna antibody, Protein snail homolog 1 antibody, Protein snail homolog antibody, SLUGH2 antibody, SNA antibody, Sna protein antibody, SNAH antibody, SNAI antibody, snai1 antibody, SNAI1_HUMAN antibody, Snail 1 homolog antibody, Snail 1 zinc finger protein antibody, SNAIL antibody, Snail family transcriptional repressor 1 antibody, Snail homolog 1 (Drosophila) antibody, SNAIL, Drosophila, homolog of, 1 antibody, SNAIL1 antibody, Zinc finger protein SNAI1 antibody

    UniProt

    O95863

    Pathways

    Negative Regulation of intrinsic apoptotic Signaling
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