SNAIL Antikörper (pSer246)
Kurzübersicht für SNAIL Antikörper (pSer246) (ABIN7138508)
Target
Alle SNAIL (SNAI1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pSer246
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Kreuzreaktivität
- Human, Maus
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Aufreinigung
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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Immunogen
- Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1.
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Isotyp
- IgG
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Applikationshinweise
- WB:1:500-1:1000, IF:1:100-1:200,
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SNAIL (SNAI1)
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Andere Bezeichnung
- SNAI1
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Hintergrund
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Background:
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Okubo T., Cancer Res. 61:1338-1346(2001).
Twigg S.R., Hum. Genet. 105:320-326(1999).
Paznekas W.A., Genomics 62:42-49(1999).Aliases: dJ710H13.1 antibody, Protein sna antibody, Protein snail homolog 1 antibody, Protein snail homolog antibody, SLUGH2 antibody, SNA antibody, Sna protein antibody, SNAH antibody, SNAI antibody, snai1 antibody, SNAI1_HUMAN antibody, Snail 1 homolog antibody, Snail 1 zinc finger protein antibody, SNAIL antibody, Snail family transcriptional repressor 1 antibody, Snail homolog 1 (Drosophila) antibody, SNAIL, Drosophila, homolog of, 1 antibody, SNAIL1 antibody, Zinc finger protein SNAI1 antibody
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UniProt
- O95863
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Pathways
- Negative Regulation of intrinsic apoptotic Signaling
Target
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