IGF2R Antikörper (pSer2409)

Produktnummer ABIN7138501

Dieses Anti-IGF2R-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IGF2R in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für IGF2R Antikörper (pSer2409) (ABIN7138501)

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGF2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-IGF2R Antikörper

Bindungsspezifität: pSer2409

Kreuzreaktivität: Human, Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 2409(Q-D-S(p)-E-D) derived from Human IGF2R.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu IGF2R

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Andere Bezeichnung: IGF2R

Hintergrund:

Background:

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Morgan D.O., Nature 329:301-307(1987).
Oshima A., J. Biol. Chem. 263:2553-2562(1988).
Killian J.K., Mamm. Genome 10:74-77(1999)

Aliases: 300 kDa mannose 6 phosphate receptor antibody, 300 kDa mannose 6-phosphate receptor antibody, Cation independent mannose 6 phosphate receptor antibody, Cation-independent mannose-6-phosphate receptor antibody, CD222 antibody, CD222 antigen antibody, CI Man 6 P receptor antibody, CI Man-6-P receptor antibody, CI MPR antibody, CI-M6PR antibody, CI-MPR antibody, CIMPR antibody, IGF 2 receptor antibody, IGF 2R antibody, IGF II receptor antibody, IGF-II receptor antibody, IGF2 receptor antibody, Igf2r antibody, Insulin like growth factor 2 receptor antibody, Insulin like growth factor II receptor antibody, Insulin-like growth factor 2 receptor antibody, Insulin-like growth factor II receptor antibody, M6P R antibody, M6P/IGF2 receptor antibody, M6P/IGF2R antibody, M6PR antibody, mannose 6 phosphate receptor antibody, mannose 6 phosphate receptor, cation independent antibody, MPR 300 antibody, MPR300 antibody, MPRI antibody, MPRI_HUMAN antibody

UniProt: P11717