SPATA13 Antikörper

Produktnummer ABIN7131154

Dieses Anti-SPATA13-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SPATA13 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für SPATA13 Antikörper (ABIN7131154)

Target: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPATA13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SPATA13 Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of Human SPATA13

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SPATA13

Target: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Andere Bezeichnung: SPATA13

Hintergrund:

Background: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

Aliases: APC-stimulated guanine nucleotide exchange factor 2 antibody, ARHGEF29 antibody, Asef2 antibody, FLJ31208 antibody, RP11-307N16.3 antibody, Spata13 antibody, Spermatogenesis-associated protein 13 antibody, SPT13_HUMAN antibody

UniProt: Q96N96