ADD2 Antikörper

Produktnummer ABIN7128257

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ADD2 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ADD2 Antikörper (ABIN7128257)

Target: ADD2 (Adducin 2 (Beta) (ADD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADD2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ADD2 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of Human ADD2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:1000-1:2000, IHC:1:15-1:50,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ADD2

Target: ADD2 (Adducin 2 (Beta) (ADD2))

Andere Bezeichnung: ADD2

Hintergrund:

Background: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

Aliases: ADD 2 antibody, ADD2 antibody, ADDB antibody, ADDB_HUMAN antibody, Adducin 2 (beta) antibody, Adducin2 antibody, Beta adducin antibody, Beta-adducin antibody, Erythrocyte adducin subunit beta antibody, OTTHUMP00000203378 antibody, OTTHUMP00000203908 antibody

UniProt: P35612

Pathways: Regulation of Actin Filament Polymerization