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Rekombinanter SIRT5 Antikörper

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch SIRT5 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7127810

Kurzübersicht für Rekombinanter SIRT5 Antikörper (ABIN7127810)

Target

Alle SIRT5 Antikörper anzeigen
SIRT5 (Sirtuin 5 (SIRT5))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 92
  • 52
  • 32
  • 6
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
Human

Wirt

  • 90
  • 12
  • 2
  • 2
Kaninchen

Klonalität

  • 86
  • 20
Monoklonal

Konjugat

  • 51
  • 17
  • 6
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SIRT5 Antikörper ist unkonjugiert

Applikation

  • 84
  • 38
  • 34
  • 20
  • 13
  • 13
  • 12
  • 10
  • 6
  • 3
  • 3
  • 2
  • 1
Immunohistochemistry (IHC), ELISA

Klon

9H12
  • Kreuzreaktivität

    Human

    Aufreinigung

    Affinity-chromatography

    Immunogen

    A synthesized peptide derived from human SIRT5

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: IHC:1:50-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    SIRT5 (Sirtuin 5 (SIRT5))

    Andere Bezeichnung

    SIRT5

    Hintergrund

    Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

    Aliases: NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5), SIRT5, SIR2L5

    UniProt

    Q9NXA8

    Pathways

    SARS-CoV-2 Protein Interaktom
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