Rekombinanter MFN2 Antikörper

Produktnummer ABIN7127622

Der Kaninchen Monoklonal Anti-MFN2-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, MFN2 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter MFN2 Antikörper (ABIN7127622)

Target: MFN2 (Mitofusin 2 (MFN2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MFN2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Klon: 10F6

Produktdetails anti-MFN2 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Mitofusin 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Andere Bezeichnung: MFN2

Hintergrund:

Background: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity).

Aliases: Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2), MFN2, CPRP1 KIAA0214

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development