Rekombinanter Menin Antikörper

Produktnummer ABIN7127614

Dieses Anti-Menin-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von Menin in WB und ELISA. Geeignet für Human.

Kurzübersicht für Rekombinanter Menin Antikörper (ABIN7127614)

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Menin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 8G11

Produktdetails anti-Menin Antikörper

Kreuzreaktivität: Human

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Menin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Andere Bezeichnung: MEN1

Hintergrund:

Background: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Aliases: Menin, MEN1, SCG2

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity